Addison’s Disease, or hypoadrenocorticism, occurs when the adrenal glands do not produce enough hormones. The adrenal glands are located just in front of the kidneys and have two parts – the cortex and the medulla.
The adrenal cortex produces mineralocorticoids (of which the most potent naturally occurring is aldosterone), which help to control the balance of sodium and potassium salts. Glucocorticoids, which are involved in metabolizing nutrients as well as in reducing inflammation and, also produces sex hormones such as estrogen and progesterone.
The adrenal medulla plays an important role in response to stress or low blood sugar (glucose). It releases epinephrine (adrenaline) and norepinephrine, which increase heart output, blood pressure, and blood glucose, and slow digestion.
Addison's Disease is a deficiency in secretion of hormones by the adrenal gland and usually mineralocorticoid and glucocorticoid hormones are both decreased.
Addison’s disease is more common in young to middle aged dogs and occasionally in horses. The disease may be familial in Standard Poodles, West Highland White Terriers, Great Danes, Bearded Collies, Portuguese Water Dogs and a variety of other breeds. The cause of the primary adrenocortical failure usually is unknown, although most cases probably result from an autoimmune process. Other causes include destruction of the adrenal gland by granulomatous disease, metastatic tumor, hemorrhage or infarction. It can also be caused by the medications used to treat overactive adrenal glands, or Cushing’s disease.
Clinical signs include intermittent vomiting, diarrhea, decreased appetite, weight loss, and sometimes dark, bloody diarrhea. Lethargy, depression, and weakness are also common. Sometimes hair loss and increased thirst and urination occurs.
The diagnosis requires laboratory testing, because no clinical signs are specific for Addison’s disease.
Pets in an acute Addisonian crisis require hospitalization and intensive care. For most dogs with hypoadrenocorticism, lifelong supplementation with mineralocorticoids is needed.
To be taken twice daily. Determine your pet’s weight and then use the easy chart below to determine the correct dose. This is the minimum dosage.
Pet's Weight Dosage
0 - 15 lb = 0.5 ml
16 - 30 lb = 1.0 ml
31 - 45 lb = 1.5 ml
46 - 60 lb = 2.0 ml
61 - 75 lb = 2.5 ml
Over 75 lb = 3.0 ml
For small animals (rabbits, ferrets), avians and reptiles use 1 drop for every 2 lb of body weight.
How to Administer
Shake well before use.The easiest method is to use the dropper provided and place the drops into your pet’s food or favorite treat. You can also use the dropper and squirt directly into the pet’s mouth. Some pets can be finicky, if this occurs consider hiding the drops in foods most pet’s love such as fish, chicken or yogurt or a favourite treat. If your pet only eats dry food then soak a few kibbles at feeding time.
For Best Results
Herbal dietary supplements are beneficial to the health and well-being of your pet and are safe for long-term use. Every pet responds to natural herbal supplements differently, therefore it is important to be consistent and administer the product daily. Supplements generally take two to four weeks to take effect, however this will vary from one animal to the next.
All NHV Natural Pet Products are pure herbal extracts and contain no artificial additives, preservatives or coloring. Shelf life after opening is 6 months and must be refrigerated after opening.
Cautions and Contraindications
Do not use Supraglan in pregnant or nursing animals. Speak to your vet before using our products. A second visit is recommended if your pet’s condition does not improve, or deteriorates after continued use of the supplements.
All information provided by NHV Natural Pet Products is for educational purposes only.
Borage (Borago officinalis) - Borage has antibacterial, antihyperlipidemic, anti-inflammatory, antiplatelet effects and it is an herb that is know for its ability to support adrenal function. Borage contains gamma-linolenic acid (GLA), an omega-6 polyunsaturated fatty acid, that has effects on components of the renin-angiotensin-aldosterone axis, balancing the secretion of aldosterone that is reduced in Addison`s disease.
Astragalus (Astragalus membranaceus) - Astragalus has properties that help to balance the immune system which can be compromised in pets with Addison`s disease. Bistort (Polygonum bistorta) Bistort is an astringent, soothing, anti-inflammatory herb that has tonic effect on the liver and kidneys. It also helps with gastrointestinal issues, like diarrhea which is one of the symptoms present in Addison`s disease.
Eleuthero (Eleutherococcus senticosus) - Eleuthero is a tonic with a modulating effect on major stress axis including pituitary glands, hypothalamus, and adrenal glands. It can increase resistance to infection that help to support the adrenal gland. In addition, it protects the immune system, and contains powerful antioxidants that help scavenge free radicals.
Wild Yam (Diocorea villosa) - Wild Yam is anti-inflammatory herb that contains steroidal saponins (dioscin, dogenin), which is used in the preparation of steroid hormones and helps normalize hormone production which is decreased in Addison` disease.
Licorice (Glycyrrhiza glabra) - Licorice is beneficial for the adrenal gland, endocrine, digestive and respiratory system. The main phytochemical of licorice is glycyrrhizic acid helps stimulate the adrenal gland. Licorice also has an anti-inflammatory action like hydrocortisone and another corticosteroid hormones.
Dandelion - Dandelion has anti-inflammatory, antineoplastic, antioxidant, endocrine, gastrointestinal, hepatic and hypoglycemic effects. Dandelion is an anti-inflammatory and tonic herb that helps protect the kidneys which can be injured when the pet presents with Addison`s disease. It can also stimulate liver secretion and improve digestion.
Silybum marianum - As renal failure frequently occurs in Addison’s disease, Milk Thistle can be very beneficial because of its renal protective effects. Several animal studies support the renal protective effects of silymarin against toxic agents. The liver protective properties of Milk Thistle can also be beneficial for pets who take pharmaceutical medications for the treatment of Addison’s disease.