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Clinical Science and Scientific Advancement of Pet Health

We are happy to share our latest clinical research conduct jointly with the University of Saskatchewan and the university of Calgary on NHV Resp-Aid. Dr. Amanda Nascimento was the lead researcher.

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THE EFFECTS OF RESP-AID ON ASTHMA

Nascimento, A. 1; Schneberger, D. 1; Thompson, B.; Sandini, T. 1; Singh, B. 1,2; Kirychuk, S.1.

1 - University of Saskatchewan 2- University of Calgary

We are happy to share our latest clinical research conduct jointly with the University of Saskatchewan and the university of Calgary on NHV Resp-Aid. Dr. Amanda Nascimento was the lead researcher.

Introduction

Asthma is a serious form of respiratory disease-causing high mortality in the world. Resp-Aid is an innovative proprietary formula developed by NHV Natural Pet Products to support respiratory disorders and bronchial infections. It is composed of 9 herbs: Coltsfoot (Tussilago farfar), Marshmallow (Althaea officilanes), Plantain (Pantago major), Mullein (Verbascum Thapsus), Horehound (Marrubium vulgare) and Licorice (Gycyrrhiza glabra), Lobelia (Lobelia inflata), Ginger (Zingiber officinale), Myrrh (Commiphora momol). These herbs have traditional been for respiratory treatments such as asthma to reduce coughing and phlegm/mucous production, and are known have anti-inflammatory and immunomodulatory activities. However, the effects of these herbs in this formula for asthma have not been scientifically studied.

Objective

Based on the theoretical benefits of Resp-Aid, we conducted a series of studies to explore the efficacy, safety and mechanism of action of Resp-Aid. We hypothesized the treatment with Resp-Aid can alter pulmonary immune responses.

Material and Method

Therefore, to study this, we treated asthmatic and non asthmatic animals with Resp-Aid. They received 1 drop of Resp-Aid twice daily for 7 days. On day 7 of the treatment with Resp-Aidwhole body plethysmography chambers ( this is an instrument that measures the changes in volume within the organ) (WBP) were utilized measuring airway hyperresponsiveness (AHR - that is a characteristic feature of asthma and consists of an increased sensitivity of the airways) and monitored for respiratory airflow. For understanding inflammatory differences between the groups, after the treatment with Resp-Aid bronchoalveolar lavage (BAL) and lungs where examined.

Results

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Asthmatic animals that received Resp-Aidhad lower AHR (They could breath better) compared to asthmatic animals that did not receive Resp-Aid(P<0.05).

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Asthmatic animals that received Resp-Aid had lower total leukocytes (inflammatory cells) compared to asthmatic animals that did not receive Resp-Aid (P<0.05).

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The lungs from asthmatic animals treated with Resp-Aid showed considerably less inflammation and histopathology compared with asthmatic animals’ lungs that did not receive Resp-Aid

Conclusion

This data shows that Resp-Aidalleviates asthma, and it may be a potential target for therapeutic intervention in allergic lung disease or asthma or other pulmonary infections.

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